Senescence and endothelial dysfunction/atherosclerosis
نویسندگان
چکیده
منابع مشابه
Deacetylase SIRT6 deaccelerates endothelial senescence.
Vascular endothelial homeostasis is critical to health and is a significant factor in many human diseases. It is established that endothelial cell (EC) dysfunction is one of the earliest pathological steps in the initiation and progression of vascular diseases such as atherosclerosis and vascular remodelling. 3 How to maintain a healthy or repair an injured endothelial lining of the vasculature...
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Most mitotically competent mammalian cell types can react to stress by undergoing a phenotypically distinctive and permanent form of growth arrest called "cellular senescence." This response has been extensively characterized in cell culture and more recently it has been found to occur also in vivo in a number of tissues. In this review I will present the case for the occurrence of senescence i...
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Logistic regression methods were used to analyse the influence of donor and storage factors on the quality of c~meas stored by organ culture in the Bristol eve bank in 1991. Averaae donor a(18 was 57 vears fsd 22. n=2770) -and time from death to en~cleation v& 8 hours (&I 7, n&782): Corneas were placed into organ culture within 27 houra (sd 10, n+2550) of donor death and were stored for 22 days...
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Senescence has been considered a programmed cellular response, parallel to apoptosis, that is turned on when a cell reaches Hayflick's limit. Once cells enter the senescence program, they cease to proliferate and undergo a series of morphological and functional changes. Studies support a central role for Rb protein in controlling this process after it receives senescent signals from the p53 and...
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RATIONALE Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity. OBJECTIVE To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in...
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ژورنال
عنوان ژورنال: Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
سال: 2011
ISSN: 0300-9173
DOI: 10.3143/geriatrics.48.142